Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 2/20 | 0.30 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980315 | 1.00 | THRB (0.34) | THRBHPGDSMN1; SMN2ACLYPIK3CA | |
| SCHEMBL29434779 | 0.92 | PIK3CA (0.34) | ACLYPIK3CANMT1PIK3C3CHRNB2 | |
| SCHEMBL22980259 | 0.92 | PIK3CA (0.34) | ACLYPIK3CANMT1PIK3C3CHRNB2 | |
| Trifluoroacetic Acid SCHEMBL22980528 | 0.92 | ACLY (0.34) | THRBHPGDSMN1; SMN2ACLYPIK3CA | |
| SCHEMBL22980450 | 0.91 | PIK3CA (0.35) | SMN1; SMN2PIK3CAPIK3C3CHRNB2CHRNA4 | |
| SCHEMBL29434829 | 0.91 | PIK3CA (0.35) | SMN1; SMN2PIK3CAPIK3C3CHRNB2CHRNA4 | |
| SCHEMBL22980440 | 0.86 | HSD11B1 (0.45) | MAP3K20SLC40A1 | |
| SCHEMBL29434864 | 0.86 | HSD11B1 (0.45) | MAP3K20SLC40A1 | |
| SCHEMBL22980302 | 0.82 | MAP3K20 (0.44) | PIK3CALMNAMAP3K20MEN1KMT2A | |
| SCHEMBL29434859 | 0.82 | MAP3K20 (0.44) | PIK3CALMNAMAP3K20MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013495-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-06-22 | — | — | EP | disclosed |