⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138677 | 0.82 | — | — | |
| SCHEMBL6238926 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL2976201 | 0.73 | LMNA (0.35) | — | |
| SCHEMBL6521956 | 0.68 | KDM4E (0.40) | — | |
| SCHEMBL9050637 | 0.68 | LMNA (0.32) | — | |
| SCHEMBL15974035 | 0.65 | LMNA (0.38) | — | |
| SCHEMBL2872028 | 0.63 | — | — | |
| SCHEMBL74108 | 0.63 | MMP13 (0.41) | — | |
| SCHEMBL2967822 | 0.63 | MMP13 (0.41) | — | |
| SCHEMBL75900 | 0.63 | MMP13 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772403-B2 | Process to prepare sulfonyl chloride derivatives | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-20090054659-A1 | Process to Prepare Sulfonyl Chloride Derivatives | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| EP-1999115-A1 | PROCESS TO PREPARE SULFONYL CHLORIDE DERIVATIVES | AstraZeneca AB (SE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007106021-A1 | PROCESS TO PREPARE SULFONYL CHLORIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| US-20060019994-A1 | I-sulphonlyl piperidine derivatives | ASTRAZENECA AB (SE) | 2006-01-26 | — | — | US | disclosed |
| EP-1539706-A1 | 1-SULPHONYL PIPERIDINE DERIVATIVES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024698-A1 | 1-SULPHONYL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |