Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595759 | 0.76 | LMNA (0.36) | LMNA | |
| SCHEMBL15974035 | 0.75 | LMNA (0.38) | ALDH1A1KDM4ECYP3A4GABRB3OPRD1 | |
| SCHEMBL4958726 | 0.74 | ALDH1A1 (0.38) | ALDH1A1KDM4ECYP3A4GABRB3OPRD1 | |
| SCHEMBL1101433 | 0.71 | MEN1 (0.35) | LMNAMAPTCYP2C9 | |
| SCHEMBL11173511 | 0.69 | LMNA (0.40) | ALDH1A1KDM4ECYP3A4GABRB3OPRD1 | |
| SCHEMBL12843938 | 0.69 | HDAC1 (0.33) | ALDH1A1MAPT | |
| SCHEMBL4620887 | 0.68 | LMNA (0.36) | ALDH1A1KDM4ECYP3A4GABRB3OPRD1 | |
| SCHEMBL10534638 | 0.68 | ADAMTS5 (0.31) | ALDH1A1KDM4ECYP3A4GABRB3OPRD1 | |
| SCHEMBL2872028 | 0.68 | — | — | |
| SCHEMBL9539755 | 0.68 | PDK2 (0.52) | ALDH1A1KDM4ELMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534774-A1 | 5,5-Dialkyl hydantoins for promoted acid gas scrubbing processes | EXXON CHEMICAL PATENTS INC. (US) | 1993-03-31 | — | — | EP | claimed |
| US-10421751-B2 | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | LYCERA CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180111922-A1 | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATEMENT OF DISEASE | LYCERA CORPORATION | 2018-04-26 | — | — | US | disclosed |
| US-8394960-B2 | Thiazole carboxamide derivatives and their use to treat cancer | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| WO-2013001498-A1 | AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES | ADAMED SP. Z O.O. (PL) | 2013-01-03 | — | — | WO | disclosed |
| US-20110044940-A1 | Thiazole Carboxamide Derivatives and Their Use to Treat Cancer | SCHERING CORPORATION | 2011-02-24 | — | — | US | disclosed |
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20080221092-A1 | Heterobicyclic metalloprotease inhibitors | BLUHM HARALD | 2008-09-11 | — | — | US | disclosed |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
| US-4883914-A | Benzenesulfonyl carboxamide compounds useful as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1989-11-28 | — | — | US | disclosed |
| EP-0303863-A2 | Benzenesulfonyl carboxamide compounds, intermediate compounds and methods of preparation thereof and use of said compounds and intermediate compounds as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4668273-A | Quaternary ammonium salts of diepoxides and diamines, their preparation and use | CIBA-GEIGY CORPORATION (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0026157-B1 | QUATERNARY AMMONIUM SALTS FROM DIEPOXYDES AND DIAMINES, THEIR PREPARATION AND THEIR USE | CIBA-GEIGY AG (CH) | 1984-06-13 | — | — | EP | disclosed |
| US-4332953-A | FOR PREPARING URETHANE FOAMS AND ELASTOMERS | BASF WYANDOTTE CORPORATION (US) | 1982-06-01 | — | — | US | disclosed |
| US-4331809-A | INTERMEDIATES FOR PREPARING POLYURETHANE FOAMS AND ELASTOMERS | BASF WYANDOTTE CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| US-4331810-A | Carbamylbiuret-modified polyisocyanates | BASF WYANDOTTE CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| US-4330636-A | Carbamylbiuret-modified polyisocyanates | BASF WYANDOTTE CORPORATION (US) | 1982-05-18 | — | — | US | disclosed |
| US-4271087-A | WHICH CAN ALSO CONTAIN GUANIDINE LINKAGES AND THIOUREA LINKAGES | BASF WYANDOTTE CORPORATION (US) | 1981-06-02 | — | — | US | disclosed |
| EP-0026157-A2 | Quaternary ammonium salts from diepoxydes and diamines, their preparation and their use | CIBA-GEIGY AG (CH) | 1981-04-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111922-A1 | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATEMENT OF DISEASE | RORB, RORA, RORC | ALDH1A1 163/4885KDM4E 2051/4885CYP3A4 502/4885 |
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | MMP13, TIMP3, MMP3 | ALDH1A1 1806/4885KDM4E 2058/4885CYP3A4 708/4885 |
| US-20110044940-A1 | Thiazole Carboxamide Derivatives and Their Use to Treat Cancer | LCK, TEC, MTOR | ALDH1A1 2981/4885KDM4E 1767/4885CYP3A4 2610/4885 |
| US-10421751-B2 | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | RORB, RORA, RORC | ALDH1A1 201/4885KDM4E 2334/4885CYP3A4 444/4885 |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | ALDH1A1 1806/4885KDM4E 2058/4885CYP3A4 708/4885 |
| US-20080221092-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, MMP3, TIMP3 | ALDH1A1 1875/4885KDM4E 2290/4885CYP3A4 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.