Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.71 |
| ▸ | SPR | P35270 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | IDO1 | P14902 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.62 |
| ▸ | FAAH | O00519 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bufobutanoic Acid SCHEMBL22804772 | 1.00 | TRPV1 (0.71) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL19051471 | 0.93 | TRPV1 (0.76) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL29679209 | 0.92 | TRPV1 (0.81) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL25137286 | 0.91 | TRPV1 (0.76) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL4686124 | 0.89 | TRPV1 (0.84) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| N-Dihydro-P-Coumaroylserotonin SCHEMBL10070986 | 0.86 | TRPV1 (0.72) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL2271234 | 0.86 | SPR (0.74) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL1960963 | 0.85 | SPR (0.78) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL15232329 | 0.85 | TRPV1 (0.76) | TRPV1SPRKDM4EALDH1A1NPSR1 | |
| SCHEMBL31036202 | 0.85 | TRPV1 (0.91) | TRPV1SPRKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118496144-A | Bufadienamine derivative and application thereof in analgesic and antidepressant drugs | 南京效真生物科技有限公司 | 2024-08-16 | — | — | CN | disclosed |
| US-20230174510-A1 | N-acetylserotonin Derivatives as TrkB Activators and Uses Thereof | EMORY UNIVERSITY | 2023-06-08 | — | — | US | disclosed |
| EP-4142714-A1 | N-ACETYLSEROTONIN DERIVATIVES AS TRKB ACTIVATORS AND USES THEREOF | Emory University (US) | 2023-03-08 | — | — | EP | disclosed |
| US-20220273620-A1 | COMPOSITIONS CONTAINING TOAD SECRETION COMPOUNDS | CAAMTECH, INC. | 2022-09-01 | — | — | US | disclosed |
| EP-4003395-A1 | COMPOSITIONS CONTAINING TOAD SECRETION COMPOUNDS | Caamtech, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174510-A1 | N-acetylserotonin Derivatives as TrkB Activators and Uses Thereof | BDNF, NTRK2, NGF | TRPV1 190/4885SPR 2524/4885KDM4E 3530/4885 |
| US-20220273620-A1 | COMPOSITIONS CONTAINING TOAD SECRETION COMPOUNDS | HTR5A, DIMT1, GART | TRPV1 1216/4885SPR 2569/4885KDM4E 2050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.