Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 10/20 | 0.35 |
| ▸ | BPTF | Q12830 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24528665 | 1.00 | NEK1 (0.36) | NEK1IKBKBCHUKJAK1BPTF | |
| SCHEMBL29681210 | 0.81 | JAK1 (0.39) | IKBKBCHUKJAK1ALDH1A1SYK | |
| SCHEMBL24528644 | 0.81 | JAK1 (0.39) | IKBKBCHUKJAK1ALDH1A1SYK | |
| SCHEMBL29681028 | 0.77 | BPTF (0.38) | NEK1IKBKBCHUKJAK1BPTF | |
| SCHEMBL24528635 | 0.77 | BPTF (0.38) | NEK1IKBKBCHUKJAK1BPTF | |
| SCHEMBL29680686 | 0.76 | TERT (0.41) | NEK1IKBKBCHUKJAK1BPTF | |
| SCHEMBL24528696 | 0.73 | KDM4E (0.41) | ALDH1A1LMNA | |
| SCHEMBL29680758 | 0.73 | KDM4E (0.41) | ALDH1A1LMNA | |
| Oxalic Acid SCHEMBL29680687 | 0.71 | JAK1 (0.43) | NEK1IKBKBCHUKJAK1 | |
| SCHEMBL24528632 | 0.71 | CYP2A6 (0.39) | IKBKBCHUKJAK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263539-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022129376-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE|TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2022-06-23 | — | — | WO | disclosed |