SCHEMBL29684247

SCHEMBL29684247

O=C(O)c1nncc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.53
KDR P35968 3/20 0.53
ALDH1A1 P00352 5/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
KDM4E B2RXH2 3/20 0.46
CYP1A2 P05177 3/20 0.46
RAB9A P51151 3/20 0.46
TP53 P04637 2/20 0.46
CYP3A4 P08684 2/20 0.46
GOT1 P17174 2/20 0.46
LMNA P02545 2/20 0.46
CYP2D6 P10635 2/20 0.46
NPC1 O15118 2/20 0.46
MPO P05164 2/20 0.46
PKM P14618 1/20 0.46
MAOA P21397 1/20 0.46
PTGS1 P23219 1/20 0.46
THPO P40225 1/20 0.46
AOX1 Q06278 1/20 0.46
ACOX1 Q15067 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL354115 1.00 EGFR (0.53) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL14993997 0.86 ALDH1A1 (0.47) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL463374 0.85 EGFR (0.47) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL27930312 0.85 ALDH1A1 (0.46) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL28279906 0.84 EGFR (0.49) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL29617978 0.83 ALDH1A1 (0.49) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL9738820 0.83 ALDH1A1 (0.49) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL30075136 0.81 EGFR (0.49) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL28194071 0.80 EGFR (0.42) EGFRKDRALDH1A1SMN1; SMN2KDM4E
SCHEMBL7016481 0.79 LMNA (0.51) EGFRKDRALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022114187-A1 COMPOUND HAVING INHIBITORY ACTION AGAINST EXCESSIVE MITOCHONDRIAL DIVISIONS 国立大学法人九州大学 2022-06-02 WO disclosed