Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | GOT1 | P17174 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MPO | P05164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.46 |
| ▸ | ACOX1 | Q15067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684247 | 1.00 | EGFR (0.53) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14993997 | 0.86 | ALDH1A1 (0.47) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL463374 | 0.85 | EGFR (0.47) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL27930312 | 0.85 | ALDH1A1 (0.46) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28279906 | 0.84 | EGFR (0.49) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29617978 | 0.83 | ALDH1A1 (0.49) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9738820 | 0.83 | ALDH1A1 (0.49) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL30075136 | 0.81 | EGFR (0.49) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28194071 | 0.80 | EGFR (0.42) | EGFRKDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7016481 | 0.79 | LMNA (0.51) | EGFRKDRALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428757-B | Heterocyclic imidazole compound, pharmaceutical composition thereof, preparation method and application thereof | 上海汇伦生物科技有限公司 | 2020-12-15 | — | — | CN | claimed |
| CN-111066779-A | Pesticide synergistic additive and method for reducing pesticide dosage | 江西中迅农化有限公司 | 2020-04-28 | — | — | CN | claimed |
| US-20180111927-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO., LTD (CN) | 2018-04-26 | — | — | US | claimed |
| EP-3284743-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Huilun Life Science & Technology Co., Ltd (CN) | 2018-02-21 | — | — | EP | claimed |
| CN-1097423-A | Quinolone-and naphthyridonecarboxylic acid derivatives | BAYER AG (DE) | 1995-01-18 | — | — | CN | claimed |
| CN-1068114-A | 7-azepine iso-dihydro-indole-group-quinolone and naphthyridonecarboxylic derivative | BAYER AG (DE) | 1993-01-20 | — | — | CN | claimed |
| CN-111989328-B | Heterocyclic derivatives as pest control agents | 拜耳公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115181067-A | Arylpyrazole compound and pest control agent | 日本曹达株式会社 | 2022-10-14 | — | — | CN | disclosed |
| CN-109195966-B | Microbiocidal thiazole derivatives | 先正达参股股份有限公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-108430980-B | Microbicidal oxadiazole derivatives | 先正达参股股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| EP-3284743-B1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HUILUN LIFE SCIENCE & TECH CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| CN-108430976-B | Arylpyrazole compound and pest control agent | 日本曹达株式会社 | 2022-07-05 | — | — | CN | disclosed |
| CN-109071520-B | Microbicidal oxadiazole derivatives | 先正达参股股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| WO-1993012087-A1 | BIS(CARBAMOYLPIPERIDYL)ALKYLENES AS PLATELET AGGREGATION INHIBITORY AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-06-24 | — | — | WO | disclosed |
| US-5219867-A | Platelet aggregation inhibitory agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-06-15 | — | — | US | disclosed |
| CN-1068114-A | 7-azepine iso-dihydro-indole-group-quinolone and naphthyridonecarboxylic derivative | BAYER AG (DE) | 1993-01-20 | — | — | CN | disclosed |
| US-4393062-A | ALDOSE REDUCTASE INHIBITOR | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-07-12 | — | — | US | disclosed |
| US-4251528-A | ALDOSE REDUCTASE INHIBITORS USEFUL IN DIABETES, GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |
| US-4182876-A | ANTAGONIST FOR THROMBOXANE A2, USED IN TREATMENT OF CEREBRAL APOPLEXY AND MYOCARDIAL INFARCTION | MASAYUKI ISHIKAWA (JP) | 1980-01-08 | — | — | US | disclosed |
| EP-0002895-A1 | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof, and process for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111927-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | PARP1, PARP8, PARP11 | EGFR 3147/4885KDR 1404/4885ALDH1A1 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.