Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24443451 | 1.00 | CCR1 (0.36) | CCR1CCR5CCR8GRM5BUB1 | |
| SCHEMBL20524478 | 0.83 | LMNA (0.43) | CCR1CCR5CCR8GRM5NOS3 | |
| SCHEMBL29689474 | 0.79 | SMN1; SMN2 (0.44) | GRM4RAB9ALMNAHTR2CSLC6A4 | |
| SCHEMBL24443475 | 0.79 | SMN1; SMN2 (0.44) | GRM4RAB9ALMNAHTR2CSLC6A4 | |
| SCHEMBL15973172 | 0.77 | CES2 (0.49) | RAB9APOLBLMNA | |
| SCHEMBL17363394 | 0.76 | KDM4E (0.41) | PDK2POLBRECQLLMNA | |
| SCHEMBL24443450 | 0.76 | ALDH1A1 (0.50) | RAB9ARECQLLMNA | |
| SCHEMBL3937375 | 0.75 | CCR1 (0.41) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL24443407 | 0.73 | CTSA (0.36) | PDK2HTR2CSLC6A4 | |
| SCHEMBL29689865 | 0.73 | CTSA (0.36) | PDK2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601232-B1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES | CURZA GLOBAL LLC (US) | 2022-11-23 | — | — | EP | disclosed |
| US-20220274949-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES | CURZA GLOBAL, LLC (US) | 2022-09-01 | — | — | US | disclosed |
| US-11339140-B2 | Compositions and methods comprising substituted 2-aminoimidazoles | CURZA GLOBAL, LLC (US) | 2022-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274949-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES | AADAC, PAICS, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | CCR1 4687/4885CCR5 3758/4885CCR8 4291/4885 |
| US-11339140-B2 | Compositions and methods comprising substituted 2-aminoimidazoles | AADAC, PAICS, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | CCR1 4687/4885CCR5 3758/4885CCR8 4291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.