Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 1/20 | 1.00 |
| ▸ | TNKS | O95271 | 1/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 1/20 | 1.00 |
| ▸ | PARP14 | Q460N5 | 1/20 | 1.00 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 1.00 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 1.00 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18548812 | 1.00 | PARP1 (1.00) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL10260277 | 0.85 | ROCK2 (0.73) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL869572 | 0.79 | PARP1 (1.00) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL6224144 | 0.78 | ALDH1A1 (0.73) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL3371602 | 0.77 | PARP1 (0.63) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL9787048 | 0.75 | L3MBTL1 (0.73) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL14297567 | 0.74 | ROCK2 (0.59) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL9644385 | 0.73 | TDP1 (0.65) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL11646427 | 0.73 | ROCK2 (0.57) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL11646129 | 0.73 | ROCK2 (0.57) | PARP1ROCK2TNKSROCK1PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119185322-A | Tetracyclic quinolone analog combination therapies for treating cancer | 生华生物科技股份有限公司 | 2024-12-27 | — | — | CN | disclosed |
| WO-2023250513-A1 | 13-MEMBERED MACROLIDE COMPOUNDS FOR TREATING DISEASES MEDIATED BY ABNORMAL PROTEIN TRANSLATION | ZIKANI THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |
| CN-114599368-A | Tetracyclic compounds and salts, compositions, and methods of use thereof | 生华生物科技股份有限公司 | 2022-06-07 | — | — | CN | disclosed |