Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | TNKS | O95271 | 1/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.63 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.63 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945488 | 0.82 | L3MBTL1 (0.50) | KMT2AL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL746079 | 0.80 | DRD4 (0.63) | KMT2AL3MBTL1TDP1MAPTMAPK1 | |
| SCHEMBL29415608 | 0.80 | DRD4 (0.63) | KMT2AL3MBTL1TDP1MAPTMAPK1 | |
| SCHEMBL23887763 | 0.78 | LTA4H (0.54) | HSD17B10KMT2AELANEL3MBTL1NSD2 | |
| SCHEMBL18548812 | 0.77 | PARP1 (1.00) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL29696002 | 0.77 | PARP1 (1.00) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL29380769 | 0.76 | MAPT (0.57) | L3MBTL1TDP1MAPTMAPK1LMNA | |
| SCHEMBL416462 | 0.76 | MAPT (0.57) | L3MBTL1TDP1MAPTMAPK1LMNA | |
| SCHEMBL10835155 | 0.76 | PARP1 (0.56) | PARP1ROCK2TNKSROCK1PARP14 | |
| SCHEMBL16038772 | 0.75 | POLB (0.56) | PARP1ROCK2TNKSROCK1PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140024583-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2014-01-23 | — | — | US | disclosed |
| US-8501746-B2 | Organic compounds | XENON PHARMACEUTICALS INC. (CA) | 2013-08-06 | — | — | US | disclosed |
| WO-2007143597-A9 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| EP-2029572-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-20090156615-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156615-A1 | ORGANIC COMPOUNDS | SCD, SCD5, FADS2 | PARP1 1798/4885ROCK2 3930/4885TNKS 1382/4885 |
| US-20140024583-A1 | ORGANIC COMPOUNDS | SCD, SCD5, FADS2 | PARP1 1798/4885ROCK2 3930/4885TNKS 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.