SCHEMBL29697027

SCHEMBL29697027

O=C(O)c1ccc2ccc(C=Cc3cc(Br)c(O)c(Br)c3)nc2c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PIM1 P11309 20/20 1.00
▸ CLK1 P49759 1/20 0.61
▸ DYRK2 Q92630 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28595477 0.86 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL7690830 0.83 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL7690832 0.83 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL29696944 0.82 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL7243809 0.82 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL29696854 0.82 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL14115819 0.82 PIM1 (1.00) PIM1CLK1DYRK2
SCHEMBL3233991 0.81 PIM1 (0.83) PIM1CLK1DYRK2
SCHEMBL3234012 0.81 PIM1 (0.83) PIM1CLK1DYRK2
SCHEMBL29696898 0.80 PIM1 (1.00) PIM1CLK1DYRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250213569-A1 METHODS AND COMPOSITIONS FOR MEASURING AND INHIBITING EXONUCLEASE ACTIVITY NEW YORK UNIVERSITY (US) 2025-07-03 — — US disclosed
WO-2022140581-A1 METHODS AND COMPOSITIONS FOR MEASURING AND INHIBITING EXONUCLEASE ACTIVITY NEW YORK UNIVERSITY (US) 2022-06-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250213569-A1 METHODS AND COMPOSITIONS FOR MEASURING AND INHIBITING EXONUCLEASE ACTIVITY DCLRE1B, RNASE1, ADAR PIM1 4605/4885CLK1 1997/4885DYRK2 3459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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