SCHEMBL29697348

SCHEMBL29697348

Brc1ccc(-c2nc3c4ccccc4c4ccccc4c3n2-c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 2/20 0.50
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
RXFP1 Q9HBX9 2/20 0.48
MAPT P10636 2/20 0.46
GAA P10253 3/20 0.43
ALDH1A1 P00352 6/20 0.42
LMNA P02545 2/20 0.42
GRM1 Q13255 1/20 0.40
PI4KA P42356 1/20 0.40
PI4K2B Q8TCG2 1/20 0.40
PI4K2A Q9BTU6 1/20 0.40
PI4KB Q9UBF8 1/20 0.40
CYP2C19 P33261 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
HSP90AA1 P07900 1/20 0.39
TSHR P16473 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2585957 1.00 DHFR (0.50) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL19786204 0.94 DHFR (0.44) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL28576110 0.92 GAA (0.44) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL2585614 0.91 MEN1 (0.46) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL30507756 0.91 MEN1 (0.46) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL19013468 0.91 ALDH1A1 (0.46) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL2586996 0.90 MAPT (0.52) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL2631757 0.89 MEN1 (0.48) DHFRMEN1KMT2AMAPTGAA
SCHEMBL19013006 0.88 DHFR (0.44) DHFRMEN1KMT2ARXFP1MAPT
SCHEMBL19012889 0.88 DHFR (0.44) DHFRMEN1KMT2ARXFP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113214254-B Hole-transport-type main body material, preparation method thereof and application thereof in preparation of organic electroluminescent device 华南理工大学 2022-07-26 CN disclosed