SCHEMBL2631757

SCHEMBL2631757

c1ccc(-c2nc3c4ccccc4c4ccccc4c3n2-c2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
GAA P10253 2/20 0.48
PI4KA P42356 1/20 0.48
PI4K2B Q8TCG2 1/20 0.48
PI4K2A Q9BTU6 1/20 0.48
PI4KB Q9UBF8 1/20 0.48
ALDH1A1 P00352 5/20 0.47
TSHR P16473 1/20 0.47
CYP2C19 P33261 1/20 0.47
MAPT P10636 3/20 0.43
HSP90AA1 P07900 1/20 0.43
AVPR1A P37288 1/20 0.41
HCAR1 Q9BXC0 1/20 0.41
LMNA P02545 1/20 0.41
MAPK1 P28482 1/20 0.40
HTT P42858 2/20 0.40
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
KDM4E B2RXH2 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28576110 0.97 GAA (0.44) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL2585614 0.95 MEN1 (0.46) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL30507756 0.95 MEN1 (0.46) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL21195750 0.93 MEN1 (0.48) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL31109976 0.93 MEN1 (0.48) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL10296294 0.92 GAA (0.48) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL30507752 0.92 GAA (0.48) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL14582723 0.92 MEN1 (0.43) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL1696798 0.91 ALDH1A1 (0.52) MEN1KMT2AGAAPI4KAPI4K2B
SCHEMBL27412107 0.91 ALDH1A1 (0.49) MEN1KMT2AGAAPI4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029055-B2 OLED with hybrid emissive layer THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-07-02 US disclosed
US-20230225147-A1 ORGANIC LIGHT-EMITTING ELEMENT KYULUX, INC. (JP) 2023-07-13 US disclosed
US-11696492-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-07-04 US disclosed
US-20220173333-A1 HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF CHANGCHUN HYPERIONS TECHNOLOGY CO., LTD (CN) 2022-06-02 US disclosed
US-20190177303-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-06-13 US disclosed
US-10080739-B2 Aryl imidazoles and their use as anti-cancer agents APTOSE BIOSCIENCES INC. (CA) 2018-09-25 US disclosed
US-9917270-B1 Organic electroluminescent device having an exciton quenching layer CYNORA GMBH (DE) 2018-03-13 US disclosed
US-9917270-B1 Organic electroluminescent device having an exciton quenching layer CYNORA GMBH (DE) 2018-03-13 US disclosed
US-9353065-B2 Heterocyclic bridged biphenyls BASF SE (DE) 2016-05-31 US disclosed
US-20150374669-A1 ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS LORUS THERAPEUTICS INC. (CA) 2015-12-31 US disclosed
US-20150137083-A1 CONJUGATED AROMATIC DERIVATIVES AND ORGANIC LIGHT EMITTING DIODE USING THE SAME NATIONAL TSING HUA UNIVERSITY (TW) 2015-05-21 US disclosed
US-20150137083-A1 CONJUGATED AROMATIC DERIVATIVES AND ORGANIC LIGHT EMITTING DIODE USING THE SAME NATIONAL TSING HUA UNIVERSITY (TW) 2015-05-21 US disclosed
US-8969372-B2 Aryl imidazoles and their use as anti-cancer agents Aptose Boisciences Inc. (CA) 2015-03-03 US disclosed
CN-103772361-A Organic semiconductor material containing carbazole, preparation method thereof, and organic electroluminescent device OCEANS KING LIGHTING SCIENCE 2014-05-07 CN disclosed
US-8628862-B2 Electroluminescent device BASF SE (DE) 2014-01-14 US disclosed
US-20120095222-A1 PHENANTHRO[9, 10-B]FURANS FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2012-04-19 US disclosed
US-20100277060-A1 ELECTROLUMINESCENT DEVICE BASF SE (DE) 2010-11-04 US disclosed
US-20100109514-A1 HETEROCYCLIC BRIDGED BIPHENYLS UDC IRELAND LIMITED (IE) 2010-05-06 US disclosed
US-20080262015-A9 Aryl imidazoles and their use as anti-cancer agents LORUS THERAPEUTICS INC. (CA) 2008-10-23 US disclosed
US-20070123553-A1 Aryl imidazoles and their use as anti-cancer agents LORUS THERAPEUTICS INC. (CA) 2007-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070123553-A1 Aryl imidazoles and their use as anti-cancer agents AHR, AADAC, CBR3 MEN1 4554/4885KMT2A 396/4885GAA 4312/4885
US-20100109514-A1 HETEROCYCLIC BRIDGED BIPHENYLS OCIAD1, SBDS, OCIAD2 MEN1 3281/4885KMT2A 3605/4885GAA 3015/4885
US-20120095222-A1 PHENANTHRO[9, 10-B]FURANS FOR ELECTRONIC APPLICATIONS P2RY10, P2RY11, P2RY12 MEN1 660/4885KMT2A 3627/4885GAA 3641/4885
US-20220173333-A1 HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF KCNH1, OCIAD2, ETFB MEN1 2438/4885KMT2A 1180/4885GAA 3510/4885
US-12029055-B2 OLED with hybrid emissive layer S1PR4, S1PR1, S1PR2 MEN1 94/4885KMT2A 2918/4885GAA 4871/4885
US-20150374669-A1 ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS AHR, CBR3, AADAC MEN1 4554/4885KMT2A 362/4885GAA 4420/4885
US-10080739-B2 Aryl imidazoles and their use as anti-cancer agents AHR, CBR3, AADAC MEN1 4554/4885KMT2A 362/4885GAA 4420/4885
US-11696492-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, ODC1 MEN1 4521/4885KMT2A 2280/4885GAA 1427/4885
US-20080262015-A9 Aryl imidazoles and their use as anti-cancer agents AHR, AADAC, CBR3 MEN1 4554/4885KMT2A 396/4885GAA 4312/4885
US-20100277060-A1 ELECTROLUMINESCENT DEVICE LEF1, PIEZO1, ETV6 MEN1 170/4885KMT2A 2793/4885GAA 1064/4885
US-20190177303-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES OR10J3, ORC3, OR51E2 MEN1 3148/4885KMT2A 3925/4885GAA 4439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.