Sugi Predict

Sugi Predict / Compounds / SCHEMBL29699377

SCHEMBL29699377

SCHEMBL29699377

Clc1ccc2cc(-c3c[nH]nn3)ccc2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 1/20 0.39
▸ AHR P35869 2/20 0.35
▸ LTA4H P09960 2/20 0.35
▸ CMA1 P23946 1/20 0.35
▸ F7 P08709 1/20 0.35
▸ F3 P13726 1/20 0.35
▸ NR4A2 P43354 1/20 0.35
▸ ALOX5 P09917 1/20 0.34
▸ NOS1 P29475 2/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ RPA1 P27694 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ DYRK1A Q13627 1/20 0.33
▸ PDGFRB P09619 2/20 0.33
▸ MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6161279 0.82 CYP1A2 (0.50) ALOX5ALDH1A1CYP1A2CYP2C9HPGD
SCHEMBL5612785 0.81 RPA1 (0.44) LTA4HALOX5RPA1CYP1A2
SCHEMBL29699384 0.80 PDGFRB (0.54) NR4A2NOS1BACE1DYRK1APDGFRB
SCHEMBL23457543 0.80 RPA1 (0.42) LTA4HRPA1ALDH1A1CYP1A2
SCHEMBL1336095 0.79 IDO1 (0.50) ALDH1A1DYRK1APDGFRBKDR
SCHEMBL23457624 0.77 LTA4H (0.50) LTA4HRPA1CYP2C9NPSR1
SCHEMBL23457485 0.77 AHR (0.41) AHRALOX5RPA1
SCHEMBL14260684 0.77 TDO2 (0.50) —
SCHEMBL30918738 0.77 AHR (0.48) AHRALDH1A1HPGDMEN1HTT
SCHEMBL27971304 0.77 AHR (0.48) AHRALDH1A1HPGDMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230088214-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-23 — — US disclosed
US-20230089374-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-23 — — US disclosed
US-20230079913-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-16 — — US disclosed
US-11384055-B2 Glycolate oxidase inhibitors for the treatment of disease BIOMARIN PHARMACEUTICAL INC. (US) 2022-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230079913-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT CYP2A6 672/4885AHR 3115/4885LTA4H 746/4885
US-20230088214-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT CYP2A6 685/4885AHR 2840/4885LTA4H 907/4885
US-11384055-B2 Glycolate oxidase inhibitors for the treatment of disease XDH, PNPO, AGXT CYP2A6 672/4885AHR 3115/4885LTA4H 746/4885
US-20230089374-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT CYP2A6 672/4885AHR 3115/4885LTA4H 746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.