Sugi Predict

Sugi Predict / Compounds / SCHEMBL29699517

SCHEMBL29699517

SCHEMBL29699517

FC(F)(F)Oc1ccc2cnc(-c3c[nH]nn3)cc2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRM4 Q14833 1/20 0.40
▸ CBFB Q13951 2/20 0.36
▸ RUNX1 Q01196 3/20 0.36
▸ CYP1A2 P05177 5/20 0.36
▸ NPC1 O15118 5/20 0.35
▸ RAB9A P51151 5/20 0.35
▸ CASP3 P42574 1/20 0.35
▸ SENP7 Q9BQF6 1/20 0.35
▸ ALOX5AP P20292 1/20 0.35
▸ FEN1 P39748 1/20 0.35
▸ SCN9A Q15858 3/20 0.34
▸ SCN7A Q01118 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ SCN10A Q9Y5Y9 1/20 0.34
▸ ABL1 P00519 2/20 0.34
▸ BCR P11274 1/20 0.34
▸ SCN4A P35499 2/20 0.33
▸ GMNN O75496 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23457511 1.00 GRM4 (0.40) GRM4CBFBRUNX1CYP1A2NPC1
SCHEMBL23457476 0.96 NPC1 (0.39) GRM4CBFBRUNX1CYP1A2NPC1
SCHEMBL23457643 0.81 CBFB (0.38) CBFBRUNX1CYP1A2NPC1RAB9A
SCHEMBL29699436 0.81 CBFB (0.38) CBFBRUNX1CYP1A2NPC1RAB9A
SCHEMBL29699410 0.79 CASP3 (0.51) CYP1A2NPC1RAB9ACASP3SENP7
SCHEMBL23457557 0.78 METAP2 (0.39) GRM4CBFBCYP1A2NPC1RAB9A
SCHEMBL29699451 0.78 METAP2 (0.39) GRM4CBFBCYP1A2NPC1RAB9A
SCHEMBL6161532 0.78 NPC1 (0.47) GRM4CYP1A2NPC1RAB9ACASP3
SCHEMBL29699371 0.76 L3MBTL1 (0.51) CYP1A2NPC1RAB9ACASP3SENP7
SCHEMBL23484469 0.73 PIM1 (0.39) GRM4RUNX1SCN9ASCN7AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230089374-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-23 — — US disclosed
US-20230088214-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-23 — — US disclosed
US-20230079913-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-16 — — US disclosed
US-11384055-B2 Glycolate oxidase inhibitors for the treatment of disease BIOMARIN PHARMACEUTICAL INC. (US) 2022-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230079913-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT GRM4 1676/4885CBFB 3669/4885RUNX1 1423/4885
US-20230088214-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT GRM4 1750/4885CBFB 3611/4885RUNX1 1420/4885
US-11384055-B2 Glycolate oxidase inhibitors for the treatment of disease XDH, PNPO, AGXT GRM4 1676/4885CBFB 3669/4885RUNX1 1423/4885
US-20230089374-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT GRM4 1676/4885CBFB 3669/4885RUNX1 1423/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.