Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30565804 | 1.00 | ALDH1A1 (0.40) | ALDH1A1AXLMERTKLMNAMAPT | |
| SCHEMBL29737121 | 0.88 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTSMN1; SMN2SLC2A1 | |
| SCHEMBL31437367 | 0.87 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2SLC2A1 | |
| SCHEMBL18289982 | 0.87 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2SLC2A1 | |
| SCHEMBL24041210 | 0.87 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2SLC2A1 | |
| SCHEMBL24041207 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTSMN1; SMN2SLC2A1 | |
| SCHEMBL22902729 | 0.82 | BTK (0.38) | ALDH1A1LMNAMAPT | |
| SCHEMBL22902458 | 0.80 | HDAC3 (0.34) | ALDH1A1AXLMERTKLMNAMAPT | |
| SCHEMBL18644660 | 0.79 | BRD4 (0.51) | JAK1 | |
| SCHEMBL32664617 | 0.79 | MCL1 (0.36) | ALDH1A1AXLMERTKLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624030-B2 | 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof | PRINCIPIA BIOPHARMA INC. (US) | 2026-05-12 | — | — | US | disclosed |
| US-20240051955-A1 | 4-AMINO-3-(4-PHENOXYPHENYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF | GENZYME CORPORATION (US) | 2024-02-15 | — | — | US | disclosed |
| EP-4267572-A1 | 4-AMINO-3-(4-PHENOXYPHENYL)-1,3- DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF | GENZYME CORPORATION (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140511-A1 | 4-AMINO-3-(4-PHENOXYPHENYL)-1,3- DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF | GENZYME CORPORATION (US) | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240051955-A1 | 4-AMINO-3-(4-PHENOXYPHENYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF | ADRA2C, P2RY4, HTR2C | ALDH1A1 1763/4885AXL 1690/4885MERTK 1414/4885 |
| US-12624030-B2 | 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof | ADRA1D, ADRA2C, P2RY1 | ALDH1A1 1367/4885AXL 897/4885MERTK 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.