Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741883 | 0.83 | MAPT (0.42) | GPR119HRH2HRH1SMN1; SMN2LMNA | |
| SCHEMBL609627 | 0.80 | GPR119 (0.48) | GPR119PIK3CAMTORLIPE | |
| SCHEMBL30512307 | 0.80 | GPR119 (0.48) | GPR119PIK3CAMTORLIPE | |
| SCHEMBL27694790 | 0.80 | MAPT (0.49) | HRH2HRH1SMN1; SMN2LMNAPOLB | |
| SCHEMBL30643624 | 0.80 | GPR119 (0.43) | GPR119HRH2HRH1SMN1; SMN2LMNA | |
| SCHEMBL29741969 | 0.79 | HPGD (0.40) | GPR119HRH2HRH1SMN1; SMN2LMNA | |
| SCHEMBL29742014 | 0.76 | TRPC6 (0.50) | GPR119HRH2HRH1SMN1; SMN2LMNA | |
| SCHEMBL29741982 | 0.74 | SMN1; SMN2 (0.40) | GPR119HRH2HRH1SMN1; SMN2LMNA | |
| SCHEMBL29936171 | 0.74 | CHRM1 (0.46) | HRH2HRH1L3MBTL1KDM4EHPGD | |
| SCHEMBL30643578 | 0.74 | FAAH (0.41) | GPR119SMN1; SMN2LMNAPOLBOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4050012-A1 | PYRIDONE BORONATES FOR THE PREPARATION OF INHIBITORS OF BTK ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2022-08-31 | — | — | EP | disclosed |
| EP-4019508-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2022-06-29 | — | — | EP | disclosed |