Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.33 |
| ▸ | TYK2 | P29597 | 5/20 | 0.33 |
| ▸ | JAK3 | P52333 | 5/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | TGM1 | P22735 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577021 | 0.85 | ALDH1A1 (0.33) | TGM2TGM1TSHR | |
| SCHEMBL29108922 | 0.83 | TGM2 (0.31) | TGM2TGM1 | |
| SCHEMBL24576969 | 0.76 | HPGD (0.44) | TSHR | |
| SCHEMBL30566577 | 0.75 | RIPK2 (0.32) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29759773 | 0.74 | JAK1 (0.40) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29760263 | 0.73 | CDC7 (0.43) | IRAK4RIPK2JAK2JAK1TYK2 | |
| SCHEMBL24576965 | 0.72 | CHEK1 (0.37) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL24576870 | 0.72 | MKNK1 (0.41) | JAK1TYK2JAK3 | |
| SCHEMBL30897429 | 0.71 | JAK2 (0.41) | IRAK4RIPK2JAK2JAK1TYK2 | |
| SCHEMBL29759991 | 0.71 | MKNK1 (0.46) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |