Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24610154 | 1.00 | APLNR (0.36) | APLNRMEN1KMT2AALDH1A1PSEN1 | |
| SCHEMBL21723770 | 0.85 | CNR2 (0.35) | APLNRMEN1KMT2AAAK1L3MBTL1 | |
| SCHEMBL21724004 | 0.79 | L3MBTL1 (0.35) | APLNRAAK1L3MBTL1SLC2A1MMP9 | |
| SCHEMBL21724002 | 0.79 | LMNA (0.40) | MEN1KMT2ASLC2A1 | |
| SCHEMBL29765181 | 0.78 | L3MBTL1 (0.41) | APLNRMEN1KMT2AALDH1A1PSEN1 | |
| SCHEMBL21741216 | 0.78 | L3MBTL1 (0.41) | APLNRMEN1KMT2AALDH1A1PSEN1 | |
| SCHEMBL24610131 | 0.75 | AAK1 (0.46) | AAK1 | |
| SCHEMBL29765084 | 0.75 | AAK1 (0.46) | AAK1 | |
| SCHEMBL28504583 | 0.74 | PDK2 (0.45) | ALDH1A1AAK1NPC1 | |
| SCHEMBL21724005 | 0.73 | LMNA (0.38) | MEN1KMT2AL3MBTL1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580224-B1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2022-07-13 | — | — | EP | disclosed |