Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29765181 | 1.00 | L3MBTL1 (0.41) | L3MBTL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20472138 | 0.85 | LDHA (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25609121 | 0.84 | ALDH1A1 (0.41) | L3MBTL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24291657 | 0.81 | ALDH1A1 (0.43) | L3MBTL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8893537 | 0.78 | LDHA (0.44) | L3MBTL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29765130 | 0.78 | APLNR (0.36) | L3MBTL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24610154 | 0.78 | APLNR (0.36) | L3MBTL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25448644 | 0.78 | HTT (0.49) | L3MBTL1ALDH1A1HTTSMN1; SMN2NR1D1 | |
| SCHEMBL30574610 | 0.78 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1HTTSMN1; SMN2NR1D1 | |
| SCHEMBL10519344 | 0.77 | LDHA (0.43) | L3MBTL1ALDH1A1HTTSMN1; SMN2NR1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11897898-B2 | Pyridine macrocycle compounds as ASK1 inhibiting agents | BIOGEN MA INC. (US) | 2024-02-13 | — | — | US | disclosed |
| EP-3837265-B1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3837265-B1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3580224-B1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2022-07-13 | — | — | EP | disclosed |
| WO-2020036946-A1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2020-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11897898-B2 | Pyridine macrocycle compounds as ASK1 inhibiting agents | MAP3K1, MAP3K19, MAP3K20 | L3MBTL1 318/4885PSEN1 1848/4885PSEN2 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.