SCHEMBL297739

SCHEMBL297739

Cc1cc(C(C)(C)c2cc(C)c(O)c(Br)c2)cc(Br)c1O

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.78
HSD17B10 Q99714 4/20 0.78
ALOX15 P16050 3/20 0.78
HIF1A Q16665 3/20 0.78
CYP3A4 P08684 3/20 0.78
ALDH1A1 P00352 3/20 0.78
ALOX12 P18054 2/20 0.78
TDP1 Q9NUW8 2/20 0.78
HPGD P15428 2/20 0.78
CASP1 P29466 1/20 0.78
RECQL P46063 1/20 0.78
CHEK1 O14757 1/20 0.64
DAPK3 O43293 1/20 0.64
RET P07949 1/20 0.64
PDGFRB P09619 1/20 0.64
PIM1 P11309 1/20 0.64
PDGFRA P16234 1/20 0.64
KDR P35968 1/20 0.64
MAPK8 P45983 1/20 0.64
RPS6KA3 P51812 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30443132 1.00 TSHR (0.78) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL16383381 0.98 TSHR (0.83) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL5953176 0.93 TSHR (0.83) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL9717849 0.89 ALOX15 (0.62) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL5173922 0.88 TSHR (1.00) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL18647 0.88 TSHR (1.00) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL2476258 0.86 TSHR (0.58) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL10013229 0.84 TSHR (0.83) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL13994267 0.84 TSHR (0.61) TSHRHSD17B10ALOX15HIF1ACYP3A4
SCHEMBL69586 0.83 ALDH1A1 (0.56) TSHRHSD17B10ALOX15HIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109274-B2 Polyarylate compositions GENERAL ELECTRIC COMPANY (US) 2006-09-19 US claimed
US-20060004152-A1 Polyarylate compositions GENERAL ELECTRIC COMPANY 2006-01-05 US claimed
EP-1560871-A1 METHOD FOR MAKING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2005-08-10 EP claimed
WO-2004041907-A1 METHOD FOR MAKING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2004-05-21 WO claimed
US-6657038-B1 Melt condensation copolymerization of dihydroxyaromatic compounds and diphenyl carbonate derivative in presence of metal hydroxide and quaternary phosphonium salt GENERAL ELECTRIC COMPANY 2003-12-02 US claimed
US-6576739-B2 Conversion of the hindered bisphenol to the corresponding bischloroformate and subsequent treatment with an amine catalyst and an aqueous base to effect polymerization by hydrolysis and condenstation of bischloroformate groups GENERAL ELECTRIC COMPANY 2003-06-10 US claimed
US-20020111456-A1 Method of polycarbonate preparation SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-08-15 US claimed
WO-2001085825-A2 METHOD OF POLYCARBONATE PREPARATION GENERAL ELECTRIC COMPANY (US) 2001-11-15 WO claimed
US-11898025-B2 Polyethylene with additives for increased environmental stress crack resistance SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2024-02-13 US disclosed
US-11535732-B2 Polyethylene with polycarbonate-siloxane for increased environmental stress crack resistance SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2022-12-27 US disclosed
US-20210388189-A1 POLYETHYLENE WITH ADDITIVES FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-12-16 US disclosed
US-20210309839-A1 POLYETHYLENE WITH POLYCARBONATE-SILOXANE FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-10-07 US disclosed
EP-3877463-A1 POLYETHYLENE WITH ADDITIVES FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC Global Technologies B.V. (NL) 2021-09-15 EP disclosed
EP-3802687-A1 POLYETHYLENE WITH POLYCARBONATE-SILOXANE FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC Global Technologies B.V. (NL) 2021-04-14 EP disclosed
US-4412057-A Process for manufacturing aromatic polyesters KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1983-10-25 US disclosed
EP-0056149-A1 Process for manufacturing aromatic polyesters KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1982-07-21 EP disclosed
EP-0050821-A1 Heat-resisting aromatic polyester resin and process for preparing the same KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1982-05-05 EP disclosed
EP-0040863-A1 Flame-retardant polycarbonate polyblends Mobay Chemical Corporation (US) 1981-12-02 EP disclosed
US-4174359-A HALOGEN COMPOUND MOBAY CHEMICAL CORPORATION (US) 1979-11-13 US disclosed
EP-0001096-A2 Flame retardant polycarbonate blends Mobay Chemical Corporation (US) 1979-03-21 EP disclosed