Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727292 | 0.88 | TSHR (0.73) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL297739 | 0.86 | TSHR (0.78) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL30443132 | 0.86 | TSHR (0.78) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL29065615 | 0.86 | TSHR (0.70) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL13994267 | 0.84 | TSHR (0.61) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL16383381 | 0.84 | TSHR (0.83) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL201609 | 0.83 | GABRA1 (0.57) | HSD17B10HIF1AALOX15TDP1ALDH1A1 | |
| SCHEMBL68929 | 0.82 | ALOX15 (0.58) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL7969192 | 0.81 | TSHR (0.59) | TSHRHSD17B10HIF1AALOX15TDP1 | |
| SCHEMBL28119481 | 0.80 | GABRA1 (0.55) | HSD17B10HIF1AALOX15TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507717-B2 | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-08-13 | — | — | US | claimed |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | W.R. GRACE & CO.-CONN. | 2010-07-08 | — | — | US | claimed |
| EP-2800745-B1 | PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORY, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES | PHENEX PHARMACEUTICALS AG (DE) | 2020-02-12 | — | — | EP | disclosed |
| US-9815851-B2 | Pyrrolo carboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases | PHENEX PHARMACEUTICALS AG (DE) | 2017-11-14 | — | — | US | disclosed |
| US-20140349987-A1 | PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORy, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES | PHENEX PHARMACEUTICALS AG (DE) | 2014-11-27 | — | — | US | disclosed |
| US-8507717-B2 | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507717-B2 | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507717-B2 | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-08-13 | — | — | US | disclosed |
| EP-2373604-A2 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | Dow Global Technologies LLC (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010078512-A2 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010078512-A2 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | W.R. GRACE & CO.-CONN. | 2010-07-08 | — | — | US | disclosed |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | W.R. GRACE & CO.-CONN. | 2010-07-08 | — | — | US | disclosed |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | W.R. GRACE & CO.-CONN. | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349987-A1 | PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORy, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES | RORA, RORB, RORC | TSHR 152/4885HSD17B10 1823/4885HIF1A 1250/4885 |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | DDT, COMT, DDC | TSHR 3690/4885HSD17B10 195/4885HIF1A 4593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.