Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 5/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27329797 | 0.82 | NPSR1 (0.38) | LMNAATRALDH1A1HTTKMT2A | |
| SCHEMBL16469156 | 0.74 | LRRK2 (0.39) | — | |
| SCHEMBL20939544 | 0.70 | PRMT5 (0.41) | ALDH1A1KMT2AKDM4EPIK3R1PIK3CA | |
| SCHEMBL28558608 | 0.69 | CREBBP (0.34) | — | |
| SCHEMBL16469651 | 0.65 | — | — | |
| SCHEMBL29777616 | 0.65 | MAP4K4 (0.36) | LMNAATRALDH1A1KDM4EPIK3CA | |
| SCHEMBL19950864 | 0.65 | RIPK2 (0.40) | LMNAALDH1A1ABL1BCR | |
| SCHEMBL29777613 | 0.65 | ALOX15 (0.34) | ALDH1A1KMT2AKDM4ETSHRCYP2C19 | |
| SCHEMBL17045302 | 0.64 | CYP11B1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL26118553 | 0.62 | DRD4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108948019-B | Focal adhesion kinase inhibitors and uses thereof | 广东东阳光药业有限公司 | 2022-07-08 | — | — | CN | disclosed |