Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16469156 | 0.74 | LRRK2 (0.39) | PRMT5WDR77ALOX15 | |
| SCHEMBL14912399 | 0.71 | MAP4K4 (0.36) | MAP4K4PIK3CAMTORALDH1A1KDM4E | |
| SCHEMBL17147100 | 0.70 | ACHE (0.35) | MAP4K4ALDH1A1KDM4ELMNAACHE | |
| SCHEMBL29777574 | 0.69 | POLB (0.41) | ALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL20939544 | 0.67 | PRMT5 (0.41) | PIK3CAALDH1A1KDM4EPRMT5WDR77 | |
| SCHEMBL14930268 | 0.66 | KDM4E (0.35) | MAP4K4ALDH1A1KDM4ELMNARXFP1 | |
| SCHEMBL15651812 | 0.65 | ALOX15 (0.43) | CDK1CDK4CCNA2CCNE1CDK2 | |
| SCHEMBL29777611 | 0.65 | LMNA (0.36) | PIK3CAALDH1A1KDM4ELMNAATR | |
| SCHEMBL8149011 | 0.64 | HSD11B1 (0.47) | MAP4K4ALDH1A1KDM4ETDP1ACHE | |
| SCHEMBL6057032 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108948019-B | Focal adhesion kinase inhibitors and uses thereof | 广东东阳光药业有限公司 | 2022-07-08 | — | — | CN | disclosed |