Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30018309 | 0.90 | SLC40A1 (0.41) | MEN1TNFCXCL8KMT2APAX8 | |
| SCHEMBL4013608 | 0.90 | NCF1 (0.44) | MEN1TNFCXCL8KMT2APAX8 | |
| SCHEMBL26922460 | 0.83 | KDM4E (0.44) | SLC40A1KDM4EL3MBTL1NPC1HSP90AA1 | |
| SCHEMBL29734917 | 0.83 | KDM4E (0.44) | SLC40A1KDM4EL3MBTL1NPC1HSP90AA1 | |
| SCHEMBL26921493 | 0.82 | LIPE (0.38) | SLC40A1KDM4EL3MBTL1NPC1HSP90AA1 | |
| SCHEMBL795284 | 0.81 | MEN1 (0.43) | MEN1KMT2ASLC40A1KDM4EL3MBTL1 | |
| SCHEMBL26920675 | 0.80 | KDM4E (0.41) | MEN1KMT2AKDM4EL3MBTL1NPC1 | |
| SCHEMBL26921299 | 0.80 | L3MBTL1 (0.33) | KDM4EL3MBTL1NPC1HSP90AA1MPI | |
| SCHEMBL25216841 | 0.78 | L3MBTL1 (0.49) | MEN1KMT2ASLC40A1KDM4EL3MBTL1 | |
| SCHEMBL26920096 | 0.77 | COMT (0.37) | KMT2AKDM4EL3MBTL1NPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4039685-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-08-10 | — | — | EP | disclosed |