Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.77 |
| ▸ | TP53 | P04637 | 5/20 | 0.77 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.68 |
| ▸ | TUBB | P07437 | 1/20 | 0.68 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.68 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.68 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.68 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.68 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.68 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.68 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.68 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.68 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.68 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.68 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.68 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.68 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 10/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29981081 | 0.94 | MAPT (0.77) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL1970288 | 0.90 | TUBB4A (0.68) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL14022521 | 0.90 | MAPT (0.74) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL998613 | 0.90 | MAPT (0.74) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL29980270 | 0.90 | MAPT (0.74) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL26908188 | 0.88 | MAPT (0.69) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL1967979 | 0.86 | TUBB4A (0.64) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL1965853 | 0.86 | BRAF (0.65) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL15152603 | 0.86 | TUBB4A (0.64) | MAPTTP53TUBB4ATUBBTUBA3C | |
| SCHEMBL15152564 | 0.85 | MAPT (0.84) | MAPTTP53TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-07-08 | — | — | US | claimed |
| WO-2008016648-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | claimed |
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-07-08 | — | — | US | disclosed |
| WO-2008016648-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | MAPT 218/4885TP53 1830/4885TUBB4A 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.