SCHEMBL29785652

SCHEMBL29785652

O=C(N/N=C\c1ccccn1)c1ccncc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 8/20 1.00
▸ NPC1 O15118 6/20 1.00
▸ KMT2A Q03164 5/20 0.83
▸ LMNA P02545 4/20 0.83
▸ MEN1 O00255 4/20 0.83
▸ SMN1; SMN2 Q16637 4/20 0.83
▸ MAPT P10636 4/20 0.75
▸ AGTR1 P30556 4/20 0.75
▸ OPRK1 P41145 4/20 0.75
▸ ALDH1A1 P00352 3/20 0.75
▸ KDM4E B2RXH2 6/20 0.73
▸ L3MBTL1 Q9Y468 1/20 0.73
▸ ASF1A Q9Y294 1/20 0.70
▸ POLB P06746 2/20 0.67
▸ GAA P10253 1/20 0.67
▸ TDP1 Q9NUW8 1/20 0.67
▸ HTT P42858 3/20 0.66
▸ MITF O75030 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30762094 1.00 RAB9A (1.00) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL13826736 1.00 RAB9A (1.00) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL28738931 1.00 RAB9A (1.00) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL13906014 0.91 RAB9A (1.00) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL3067021 0.91 RAB9A (1.00) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL13906013 0.87 RAB9A (0.81) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL12746286 0.86 RAB9A (0.76) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL23062734 0.86 RAB9A (0.79) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL10804555 0.86 RAB9A (0.86) RAB9ANPC1KMT2ALMNAMEN1
SCHEMBL12746295 0.86 RAB9A (1.00) RAB9ANPC1KMT2ALMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250275946-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2025-09-04 — — US claimed
US-20240252594-A1 COMBINATION THERAPY FOR NEURODEGENERATIVE DISEASES ALETA NEUROSCIENCE LLC (US) 2024-08-01 — — US claimed
US-20240058288-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY ALETA NEUROSCIENCE LLC (US) 2024-02-22 — — US claimed
WO-2023042178-A2 COMBINATION THERAPY FOR NEURODEGENERATIVE DISEASES ALETA NEUROSCIENCE, LLC (US) 2023-03-23 — — WO claimed
WO-2022224118-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY ALETA NEUROSCIENCE, LLC (US) 2022-10-27 — — WO claimed
WO-2022169634-A9 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2022-09-22 — — WO claimed
WO-2022169634-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2022-08-11 — — WO claimed
US-20250275946-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2025-09-04 — — US disclosed
CN-115066424-B Kv3 modulators 奥蒂福尼疗法有限公司 2024-12-27 — — CN disclosed
US-20240252594-A1 COMBINATION THERAPY FOR NEURODEGENERATIVE DISEASES ALETA NEUROSCIENCE LLC (US) 2024-08-01 — — US disclosed
CN-118267386-A Modulators of KV3 channels for the treatment of pain 奥提芙尼治疗学有限公司 2024-07-02 — — CN disclosed
CN-108472288-B Modulators of KV3 channels for the treatment of pain 奥提芙尼治疗学有限公司 2024-05-28 — — CN disclosed
US-20240058288-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY ALETA NEUROSCIENCE LLC (US) 2024-02-22 — — US disclosed
CN-112703300-B Apparatus and method for performing a combined power cycle to generate mechanical energy 哈维尔·卡洛斯·维洛斯·莫埃达诺 2023-08-22 — — CN disclosed
WO-2023042178-A2 COMBINATION THERAPY FOR NEURODEGENERATIVE DISEASES ALETA NEUROSCIENCE, LLC (US) 2023-03-23 — — WO disclosed
WO-2022224118-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY ALETA NEUROSCIENCE, LLC (US) 2022-10-27 — — WO disclosed
WO-2022169634-A9 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2022-09-22 — — WO disclosed
WO-2022169634-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2022-08-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240058288-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY BAG3, BAG2, PHB1 RAB9A 572/4885NPC1 1507/4885KMT2A 1553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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