Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.60 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29787346 | 0.92 | TLR8 (0.72) | TLR7TLR8SLC2A1KDM4EALDH1A1 | |
| SCHEMBL22806917 | 0.92 | TLR8 (0.72) | TLR7TLR8SLC2A1KDM4EALDH1A1 | |
| SCHEMBL5507108 | 0.83 | TLR7 (0.57) | TLR7TLR8SLC2A1KDM4EALDH1A1 | |
| SCHEMBL1232530 | 0.83 | TLR7 (0.85) | TLR7TLR8ADORA3ADORA2AADORA1 | |
| SCHEMBL5507105 | 0.81 | TLR8 (0.41) | TLR7TLR8SLC2A1MAPTTSHR | |
| SCHEMBL17083434 | 0.80 | MAOA (0.46) | TLR7TLR8KDM4ETDP1MAOA | |
| SCHEMBL14323257 | 0.77 | ADORA3 (0.48) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL1233701 | 0.75 | TLR8 (1.00) | TLR7TLR8ADORA3ADORA2AADORA1 | |
| SCHEMBL29720427 | 0.75 | TLR8 (1.00) | TLR7TLR8ADORA3ADORA2AADORA1 | |
| SCHEMBL22445125 | 0.74 | TLR8 (0.50) | TLR7TLR8KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869043-A2 | PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107853-A2 | PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |