Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.57 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506468 | 0.83 | TLR7 (0.60) | TLR7TLR8KMT2AKDM4EALDH1A1 | |
| SCHEMBL1232530 | 0.81 | TLR7 (0.85) | TLR7TLR8ADORA3ADORA2AADORA1 | |
| SCHEMBL5505166 | 0.76 | ADORA3 (0.62) | KMT2AADORA3ADORA2AADORA1 | |
| SCHEMBL29787346 | 0.76 | TLR8 (0.72) | TLR7TLR8KMT2AKDM4EALDH1A1 | |
| SCHEMBL22806917 | 0.76 | TLR8 (0.72) | TLR7TLR8KMT2AKDM4EALDH1A1 | |
| SCHEMBL3992191 | 0.73 | TLR8 (0.51) | TLR7TLR8KMT2AKDM4EALDH1A1 | |
| SCHEMBL29720427 | 0.73 | TLR8 (1.00) | TLR7TLR8ADORA3ADORA2AADORA1 | |
| SCHEMBL1233701 | 0.73 | TLR8 (1.00) | TLR7TLR8ADORA3ADORA2AADORA1 | |
| SCHEMBL1234050 | 0.69 | TLR7 (0.75) | TLR7TLR8TSHRLMNAPOLB | |
| SCHEMBL18470455 | 0.69 | KMT2A (1.00) | KMT2AKDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863813-A2 | PYRAZOLO[3,4-C]QUINOLINES, PYRAZOLO[3,4-C]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107771-A2 | PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |