Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ADIPOR2 | Q86V24 | 1/20 | 0.48 |
| ▸ | ADIPOR1 | Q96A54 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987483 | 0.90 | ATF4 (0.61) | ATF4ALDH1A1POLBUSP2ADIPOR2 | |
| SCHEMBL2976726 | 0.89 | MCHR1 (0.54) | POLBSMN1; SMN2MCHR1 | |
| SCHEMBL5159218 | 0.88 | ATF4 (0.46) | ATF4ALDH1A1POLBADAMTS5ADAMTS4 | |
| SCHEMBL2978761 | 0.84 | ATF4 (0.65) | ATF4ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL2987178 | 0.83 | ATF4 (0.58) | ATF4POLBLMNASMN1; SMN2KMT2A | |
| SCHEMBL5162540 | 0.83 | MCHR1 (0.46) | POLBMCHR1 | |
| SCHEMBL2985870 | 0.82 | ATF4 (0.59) | ATF4ALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL2981366 | 0.82 | EPHX2 (0.50) | KMT2AMEN1 | |
| SCHEMBL2981298 | 0.82 | ATF4 (0.56) | ATF4ALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL2983707 | 0.81 | POLB (0.53) | ATF4POLBUSP2ADIPOR2ADIPOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | claimed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | DPYD, PKD1, AOC1 | ATF4 1845/4885ALDH1A1 207/4885POLB 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.