SCHEMBL2979078

SCHEMBL2979078

CNC(=O)CC(NC(=O)O)C1CCN(Cc2cccc(Oc3ncccn3)c2)CC1

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 5/20 0.50
SIGMAR1 Q99720 1/20 0.46
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
LMNA P02545 1/20 0.43
GAA P10253 1/20 0.43
DRD2 P14416 1/20 0.42
DRD4 P21917 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2983164 0.86 CCR8 (0.55) CCR8KDM4EALDH1A1DRD2
SCHEMBL2969750 0.84 CHRM4 (0.49) CCR8KDM4EALDH1A1MAPTDRD2
SCHEMBL2972276 0.80 SIGMAR1 (0.56) SIGMAR1DRD4
SCHEMBL2979082 0.77 CCR8 (0.48) CCR8SIGMAR1KDM4ELMNA
SCHEMBL3598498 0.77 CCR8 (0.53) CCR8SIGMAR1KDM4EALDH1A1MAPT
SCHEMBL2982160 0.76 MCHR1 (0.49)
SCHEMBL2970163 0.76 SIGMAR1 (0.49) SIGMAR1KDM4EALDH1A1
SCHEMBL2975513 0.75 DRD2 (0.46) CCR8KDM4EALDH1A1DRD2
SCHEMBL2979087 0.75 CCR8 (0.46) CCR8SIGMAR1KDM4EALDH1A1MAPT
Hydrochloric Acid SCHEMBL2971258 0.75 SIGMAR1 (0.48) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7781590-B2 Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors SANOFI-AVENTIS (FR) 2010-08-24 US disclosed
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, CNR2 CCR8 2508/4885SIGMAR1 2200/4885KDM4E 1997/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.