Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Flurazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.49 |
| ▸ | GABRA5 known ✓ | P31644 | 4/20 | 0.49 |
| ▸ | GABRA3 known ✓ | P34903 | 4/20 | 0.49 |
| ▸ | GABRA2 known ✓ | P47869 | 4/20 | 0.49 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.49 |
| ▸ | GABRG2 known ✓ | P18507 | 3/20 | 0.49 |
| ▸ | GABRB3 known ✓ | P28472 | 3/20 | 0.49 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.49 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.49 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.49 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.49 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.49 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.49 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.49 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.49 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | GHSR | Q92847 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flurazepam SCHEMBL29565153 | 1.00 | OPRK1 (1.00) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL10587083 | 1.00 | OPRK1 (1.00) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL29368156 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL29794 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL30690402 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL18396062 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL5499515 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL29792 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL29378257 | 0.99 | OPRK1 (0.98) | OPRK1DRD3KCNH2GHSRHTR1A | |
| Flurazepam SCHEMBL1650117 | 0.98 | OPRK1 (0.96) | OPRK1DRD3KCNH2GHSRHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 18650 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260115192-A1 | PHARMACEUTICAL COMPOSITIONS | SHENZHEN PHARMACIN CO LTD (CN) | 2026-04-30 | — | — | US | claimed |
| US-20260115161-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | LAMINAR PHARMACEUTICALS S A (ES) | 2026-04-30 | — | — | US | claimed |
| US-20260108529-A1 | FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, AGE-RELATED HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC (US) | 2026-04-23 | — | — | US | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260076953-A1 | METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-03-19 | — | — | US | claimed |
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| EP-0106335-A2 | Pharmaceutical composition and a method for enhancing the absorption of a pharmaceutically active compound | Tanabe Seiyaku Co., Ltd. (JP) | 1984-04-25 | — | — | EP | claimed |
| EP-0098113-A1 | A combination of beta-adrenoceptor antagonists and anxiolytic agents | AYERST, MCKENNA AND HARRISON INC. (CA) | 1984-01-11 | — | — | EP | claimed |
| WO-1983003968-A1 | BRAIN-SPECIFIC DRUG DELIVERY | UNIVERSITY OF FLORIDA (US) | 1983-11-24 | — | — | WO | claimed |
| US-4316897-A | TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | claimed |
| EP-0025546-A2 | Therapeutical use of tranquillizing benzodiazepine derivatives and mixtures containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-03-25 | — | — | EP | claimed |
| EP-0022771-A4 | RADIO RECEPTOR ASSAY FOR BENZODIAZEPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS. | US HEALTH (US) | 1981-02-04 | — | — | EP | claimed |
| EP-0022771-A1 | RADIO RECEPTOR ASSAY FOR BENZODIAZEPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS | THE UNITED STATES OF AMERICA, represented by DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1981-01-28 | — | — | EP | claimed |
| WO-1980000750-A1 | RADIO RECEPTOR ASSAY FOR BENZODIZAPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS | US COMMERCE (US) | 1980-04-17 | — | — | WO | claimed |
| US-4028467-A | Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |
| US-4028466-A | Analgesic compositions comprising dextro-propoxyphene and benzodiazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |