Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977681 | 0.85 | ALDH1A1 (0.55) | KDM4EGAAADORA2AADORA1ALDH1A1 | |
| SCHEMBL9697450 | 0.77 | SMN1; SMN2 (0.47) | KDM4EGLAGAACYP11B2ADORA2A | |
| SCHEMBL30804680 | 0.75 | ALDH1A1 (0.56) | KDM4EGLAGAACYP11B2ADORA1 | |
| SCHEMBL2979399 | 0.74 | ADORA2A (0.48) | KDM4EGLAGAACYP11B2ADORA2A | |
| SCHEMBL2974175 | 0.74 | SQOR (0.41) | KDM4EGLAGAAALDH1A1KMT2A | |
| SCHEMBL30786742 | 0.73 | ALDH1A1 (0.49) | KDM4EGLAGAACYP11B2ADORA2A | |
| SCHEMBL7100991 | 0.72 | KDM4E (0.58) | KDM4EGLAGAACYP11B2ADORA2A | |
| SCHEMBL27756524 | 0.72 | CYP2A6 (0.46) | KDM4ECYP11B2NUDT1ALDH1A1CYP1A2 | |
| SCHEMBL16501607 | 0.71 | NUDT1 (0.42) | KDM4EGLAGAACYP11B2NUDT1 | |
| SCHEMBL28721464 | 0.71 | KDM4E (0.50) | KDM4EGLAGAACYP11B2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |