Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603670 | 0.70 | HRH3 (0.73) | HRH3HRH4ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL9393545 | 0.69 | HRH3 (0.71) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL531089 | 0.68 | HRH3 (0.70) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL8250796 | 0.67 | KDM4E (0.52) | HRH3HSD11B1CYP3A4ALDH1A1LMNA | |
| SCHEMBL2979417 | 0.67 | KMT2A (0.56) | HSD11B1CYP3A4ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11251947 | 0.66 | HRH3 (0.67) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL3973791 | 0.66 | TRPM8 (0.44) | HRH3HSD11B1CYP3A4ALDH1A1MAPT | |
| SCHEMBL12082363 | 0.66 | HRH3 (0.77) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL24158294 | 0.66 | HRH3 (0.65) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL365219 | 0.66 | ALDH1A1 (0.55) | HRH3HRH4CYP3A4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| EP-1578416-B1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2006-08-02 | — | — | EP | disclosed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
| EP-1578416-A1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058248-A1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | THPO, ADCYAP1R1, DPYD | HRH3 1443/4885HRH4 396/4885HSD11B1 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.