Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.70 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.70 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.70 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430217 | 0.91 | GABRA1 (0.81) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 | |
| SCHEMBL5739049 | 0.89 | GABRA1 (0.82) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL22445235 | 0.86 | GABRA1 (0.56) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL30539775 | 0.86 | GABRA1 (0.56) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL6421158 | 0.84 | IMPDH2 (0.63) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL5245797 | 0.84 | CA12 (0.56) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL497746 | 0.84 | NR4A2 (0.78) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL22864631 | 0.83 | NR4A2 (0.54) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL29800593 | 0.83 | NR4A2 (0.54) | GABRA1GABRB2GABRB1GABRA3NR4A2 | |
| SCHEMBL7381114 | 0.82 | GABRA1 (1.00) | GABRA1GABRB2GABRB1GABRA3NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101070319-B | Crystal form of anti-hepatitis B virus compound and preparation method and application thereof | SHENGYANG ZHONGHAI BIOLOG TECHNOLOGY DEV CO LTD | 2012-04-18 | — | — | CN | disclosed |
| CN-101070319-A | Crystal form of anti-hepatitis B virus compound and preparation method and application thereof | SHENGYANG ZHONGHAI BIOLOG TECH (CN) | 2007-11-14 | — | — | CN | disclosed |
| US-6951880-B2 | Aryl and heteroaryl compounds as antibacterial and antifungal agents | GENELABS TECHNOLOGIES, INC. (US) | 2005-10-04 | — | — | US | disclosed |
| WO-2004047724-A2 | ARYL AND HETEROARYL COMPOUNDS AS ANTIBACTERIAL AND ANTIFUNGAL AGENTS | GENELABS TECHNOLOGIES, INC (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20030220340-A1 | Aryl and heteroaryl compounds as antibacterial and antifungal agents | GLAXOSMITHKLINE LLC | 2003-11-27 | — | — | US | disclosed |
| US-6436965-B1 | INHIBITION OF PHOSPHODIESTERASE; 3-CARBOCYCLIC(ALKYL)OXY-2-ARYL(ALKYL)AMINOCARBONYL-1-ARYL(ALKYL)INDOLE OR AZAINDOLE DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2002-08-20 | — | — | US | disclosed |
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2002-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220340-A1 | Aryl and heteroaryl compounds as antibacterial and antifungal agents | AADAC, ERG28, LSS | GABRA1 3237/4885GABRB2 3286/4885GABRB1 3253/4885 |
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | PDE3A, PDE3B, PDE4A | GABRA1 2868/4885GABRB2 3217/4885GABRB1 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.