Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24732842 | 0.81 | SMN1; SMN2 (0.40) | TP53SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL29756227 | 0.80 | LMNA (0.39) | SMN1; SMN2DCTPP1MERTKCNR2NPC1 | |
| SCHEMBL27213608 | 0.80 | LMNA (0.39) | SMN1; SMN2DCTPP1MERTKCNR2NPC1 | |
| SCHEMBL25381487 | 0.78 | LMNA (0.47) | SMN1; SMN2DCTPP1NPC1RAB9AAPLNR | |
| SCHEMBL4766444 | 0.76 | DCTPP1 (0.43) | DCTPP1MERTKCNR2NPC1RAB9A | |
| SCHEMBL18398215 | 0.74 | DCTPP1 (0.42) | SMN1; SMN2DCTPP1MERTKNPC1RAB9A | |
| SCHEMBL21542641 | 0.73 | DCTPP1 (0.47) | DCTPP1MERTKNPC1RAB9AEGFR | |
| SCHEMBL10074072 | 0.73 | HASPIN (0.40) | SMN1; SMN2KMT2AGAATLR7ALDH1A1 | |
| SCHEMBL3787500 | 0.72 | MERTK (0.59) | DCTPP1MERTKNPC1TXNRD1HTT | |
| SCHEMBL24732809 | 0.72 | SMN1; SMN2 (0.43) | TP53SMN1; SMN2NPC1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117736210-A | Aromatic heterocyclic compound, and preparation method and application thereof | 上海翊石医药科技有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-114805341-B | Aromatic heterocyclic compound, and preparation method and application thereof | 上海翊石医药科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-114805341-A | Aromatic heterocyclic compounds and preparation method and application thereof | 上海翊石医药科技有限公司 | 2022-07-29 | — | — | CN | disclosed |