Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29812688 | 0.87 | MAPT (0.40) | MAPTNPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL23147598 | 0.87 | MAPT (0.40) | MAPTNPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29812395 | 0.85 | MAPT (0.47) | MAPTLRRK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29812726 | 0.85 | LRRK2 (0.42) | MAPTLRRK2NPC1RAB9AKDM4E | |
| SCHEMBL30174281 | 0.83 | GABRA5 (0.36) | LRRK2NPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL29812433 | 0.82 | LRRK2 (0.38) | LRRK2GRM2SLC9A1 | |
| SCHEMBL29812046 | 0.81 | LRRK2 (0.50) | MAPTLRRK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29812252 | 0.73 | SQOR (0.47) | MAPTGRM2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23147590 | 0.73 | MAPT (0.46) | MAPTALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL23146800 | 0.72 | RAB9A (0.47) | MAPTNPC1RAB9ASMN1; SMN2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787144-A | Pyridone compounds and methods for modulating protein kinases | 埃克塞里艾克西斯公司 | 2022-07-22 | — | — | CN | disclosed |