Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095516 | 1.00 | MEN1 (0.64) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL6358441 | 0.89 | MAPT (0.60) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL31042567 | 0.86 | SLC6A4 (0.54) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL7061242 | 0.86 | MAPT (0.61) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL5696296 | 0.86 | ABL1 (0.56) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL1484183 | 0.85 | ABL1 (0.64) | MEN1KMT2ALMNAKCNMA1ALDH1A1 | |
| SCHEMBL11306685 | 0.85 | LMNA (0.63) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL17133624 | 0.84 | ABL1 (0.54) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL7414042 | 0.84 | ABL1 (0.54) | MEN1KMT2ALMNAMAPTKCNMA1 | |
| SCHEMBL11289664 | 0.84 | MEN1 (0.71) | MEN1KMT2ALMNAMAPTKCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294800-A1 | APOL1 INHIBITORS AND METHODS OF USE | Maze Therapeutics, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022178315-A1 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2022-08-25 | — | — | WO | disclosed |