Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696296 | 0.88 | ABL1 (0.56) | ABL1KMT2AMEN1ALDH1A1NR4A2 | |
| SCHEMBL3691064 | 0.84 | KMT2A (0.61) | KMT2AMEN1ALDH1A1LMNACFD | |
| SCHEMBL29812845 | 0.84 | MEN1 (0.64) | ABL1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL1095516 | 0.84 | MEN1 (0.64) | ABL1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL329298 | 0.83 | CFD (0.69) | KMT2AALDH1A1LMNACFDKDM4E | |
| SCHEMBL239981 | 0.83 | CFD (0.50) | KMT2AMEN1ALDH1A1LMNACFD | |
| SCHEMBL7803837 | 0.83 | KMT2A (0.47) | KMT2AMEN1ALDH1A1LMNACFD | |
| SCHEMBL10890222 | 0.83 | LMNA (0.51) | ABL1KMT2AMEN1ALDH1A1NR4A2 | |
| SCHEMBL2946505 | 0.81 | SLC6A3 (0.68) | ABL1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11226472 | 0.81 | HSD17B10 (0.51) | KMT2AMEN1ALDH1A1LMNACFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022268145-A1 | AMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 中国科学院上海药物研究所 | 2022-12-29 | — | — | WO | disclosed |
| CN-115504940-A | Amide compound, preparation method and pharmaceutical application thereof | 中国科学院上海药物研究所 | 2022-12-23 | — | — | CN | disclosed |
| US-4935511-A | Nervous system, gastrointestinal disorders | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |