Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 14/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298411 | 0.94 | PAK1 (0.48) | PAK1ALKPAK4MKNK1MKNK2 | |
| SCHEMBL297658 | 0.85 | DYRK1A (0.43) | PAK1KCNH2ATMPAK4MKNK1 | |
| SCHEMBL298640 | 0.83 | BRAF (0.37) | PAK1PAK4PDPK1CYP2C19MAP3K11 | |
| SCHEMBL299284 | 0.83 | BRAF (0.45) | PAK1CYP2C19 | |
| SCHEMBL298248 | 0.81 | PAK1 (0.56) | PAK1ALKPAK4MKNK1MKNK2 | |
| SCHEMBL298435 | 0.81 | PAK1 (0.51) | PAK1ALKPAK4MKNK1MKNK2 | |
| SCHEMBL298910 | 0.80 | CAMKK2 (0.44) | MKNK1MKNK2 | |
| SCHEMBL299489 | 0.79 | PAK1 (0.49) | PAK1ALKPAK4MKNK1MKNK2 | |
| SCHEMBL3704923 | 0.78 | PAK1 (0.56) | PAK1ALKPAK4MKNK1MKNK2 | |
| SCHEMBL299033 | 0.77 | BRAF (0.46) | PAK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |