Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297658 | 0.87 | DYRK1A (0.43) | CAMKK2NEK2KDRCDK2MKNK1 | |
| SCHEMBL299284 | 0.85 | BRAF (0.45) | CAMKK2MAP2K1NEK2KDRBRAF | |
| SCHEMBL298640 | 0.85 | BRAF (0.37) | CAMKK2MAP2K1NEK2KDRBRAF | |
| SCHEMBL297931 | 0.81 | BRAF (0.43) | CAMKK2MAP2K1NEK2KDRHAT1 | |
| SCHEMBL298168 | 0.80 | PAK1 (0.49) | MKNK1MKNK2 | |
| SCHEMBL299033 | 0.78 | BRAF (0.46) | MAP2K1NEK2KDRBRAFPKM | |
| SCHEMBL3711232 | 0.76 | CAMKK2 (0.54) | CAMKK2MAP2K1NEK2KDRADORA2A | |
| SCHEMBL3709076 | 0.73 | NEK2 (0.63) | CAMKK2MAP2K1NEK2KDRADORA2A | |
| SCHEMBL298411 | 0.73 | PAK1 (0.48) | MKNK1MKNK2 | |
| SCHEMBL297872 | 0.72 | CYP2C9 (0.48) | MAP2K1NEK2KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |