Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.49 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isonicotinic Acid SCHEMBL28136907 | 0.87 | NAPRT (0.71) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Benzoic Acid SCHEMBL28033008 | 0.79 | NAPRT (0.48) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Isonicotinic Acid SCHEMBL8358038 | 0.79 | NAPRT (0.85) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Benzoic Acid SCHEMBL2514951 | 0.77 | NAPRT (0.74) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Isonicotinic Acid SCHEMBL1414914 | 0.77 | NAPRT (1.00) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Isonicotinic Acid SCHEMBL1108 | 0.77 | — | — | |
| Benzoic Acid SCHEMBL5323571 | 0.77 | NAPRT (0.54) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Niacin SCHEMBL5485587 | 0.75 | ALDH1A1 (0.78) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Benzoic Acid SCHEMBL2514725 | 0.75 | NAPRT (0.70) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Benzoic Acid SCHEMBL3811105 | 0.75 | NAPRT (0.70) | NAPRTALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194399-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | NAPRT 4011/4885ALDH1A1 2257/4885CYP1A2 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.