Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | APP | P05067 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.78 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.78 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacin SCHEMBL28284407 | 0.98 | ALDH1A1 (0.75) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL150011 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL29396199 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL29349574 | 0.88 | — | — | |
| Niacin SCHEMBL1433 | 0.88 | — | — | |
| Niacin SCHEMBL28292236 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL3081560 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL30844065 | 0.88 | — | — | |
| Niacin SCHEMBL23780926 | 0.86 | ALDH1A1 (0.95) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL23780929 | 0.86 | ALDH1A1 (0.95) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103974948-B | Substituted benzyl indazoles as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases | 拜耳医药股份有限公司 | 2017-07-28 | — | — | CN | claimed |
| CN-105218546-B | Synthesis process of 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether | 上海泰坦科技股份有限公司 | 2017-05-17 | — | — | CN | claimed |
| CN-104583197-B | New bicyclicpyridine derivatives | 霍夫曼-拉罗奇有限公司 | 2017-05-17 | — | — | CN | claimed |
| CN-100571704-C | Fixed dosage antitubercular agent compound pharmaceutical and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-12-23 | — | — | CN | claimed |
| CN-1611218-A | Fixed dose compound preparation of antitubercular drug and its preparing method | UNIV SHENYANG PHARMACEUTICAL (CN) | 2005-05-04 | — | — | CN | claimed |
| CN-107074800-B | substituted bicyclic heteroaryl compounds as RXR agonists | 康内克斯生命科学私人有限公司 | 2019-11-12 | — | — | CN | disclosed |
| CN-110372699-A | A kind of synthetic method of the excessive state impurity of Eliquis | 新乡双鹭药业有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110225758-A | The alimentation composition of the dietary management of eilema is provided | MJN 美国控股有限责任公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-105473554-B | Condensed piperidine amide as ion channel modulators | 沃泰克斯药物股份有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-110036009-A | Substituted pyrrolidines and their use in the treatment of cystic fibrosis | 艾伯维公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-110035993-A | SUBSTITUTED PYRROLIDINES AS CFTR MODULATORS | 艾伯维公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-110022875-A | Therapeutic inhibiting compound | 莱福斯希医药公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-106659228-A | Nutritional compositions relating to subjects with cow's milk protein allergy | MJN 美国控股有限责任公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-106588916-A | N-(phenoxyethyl) imidazo [1,2-a] pyridine-3-amide compound and preparation method thereof | 浙江司太立制药股份有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-104981470-B | Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use | 拜耳制药股份公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104114553-B | Substituted pyrazolo [1,5 a] pyridine as tropomyosin receptor kinase (Trk) inhibitor | 雷迪博士实验室有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-100571704-C | Fixed dosage antitubercular agent compound pharmaceutical and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-12-23 | — | — | CN | disclosed |
| CN-100515419-C | Substituted benzazoles and its application as inhibitors of Raf kinase | CHIRON CORP (US) | 2009-07-22 | — | — | CN | disclosed |
| US-20070299091-A1 | Azaindole Carboxamides | GMEINER PETER | 2007-12-27 | — | — | US | disclosed |
| CN-1611218-A | Fixed dose compound preparation of antitubercular drug and its preparing method | UNIV SHENYANG PHARMACEUTICAL (CN) | 2005-05-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299091-A1 | Azaindole Carboxamides | TPH1, TPH2, HTR1A | ALDH1A1 505/4885APP 3220/4885GAA 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.