Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | TET3 | O43151 | 7/20 | 0.47 |
| ▸ | FBXL19 | Q6PCT2 | 7/20 | 0.47 |
| ▸ | CXXC5 | Q7LFL8 | 7/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 7/20 | 0.47 |
| ▸ | CXXC4 | Q9H2H0 | 7/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 5/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19889017 | 0.84 | HSD11B1 (0.46) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL29724136 | 0.82 | GRM5 (0.47) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL29724127 | 0.81 | TET3 (0.38) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL20849781 | 0.81 | TET3 (0.45) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL25870417 | 0.80 | KMT2A (0.43) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL167151 | 0.79 | TET3 (0.47) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL237862 | 0.79 | — | — | |
| SCHEMBL20547259 | 0.79 | TET3 (0.47) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL12764449 | 0.79 | TET3 (0.47) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL17150549 | 0.77 | TET3 (0.43) | KMT2ATET3FBXL19CXXC5KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853739-B | Acetylenic pyrazine FGFR inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-114853739-A | Alkynyl pyrazine FGFR inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2022-08-05 | — | — | CN | disclosed |