Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258763 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TSHRALKBH2EGLN1DAO | |
| SCHEMBL2539770 | 0.80 | ALDH1A1 (0.54) | ALDH1A1TSHRMEN1LMNAKMT2A | |
| SCHEMBL297463 | 0.79 | PDE4B (0.50) | ALDH1A1TSHRPDE4BPDE4DMEN1 | |
| SCHEMBL296528 | 0.77 | ALDH1A1 (0.47) | ALDH1A1TSHRPDE4BPDE4DKDM4E | |
| SCHEMBL28127748 | 0.75 | KDM4E (0.44) | ALDH1A1TSHRPDE4BDAOPDE4D | |
| SCHEMBL3758947 | 0.75 | MCL1 (0.56) | ALDH1A1PDE4BDAOMEN1LMNA | |
| SCHEMBL29904565 | 0.75 | KDM4E (0.44) | ALDH1A1TSHRPDE4BDAOPDE4D | |
| SCHEMBL30226404 | 0.75 | PARP1 (0.45) | ALDH1A1TSHRPDE4BDAOPDE4D | |
| SCHEMBL23672389 | 0.75 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL953080 | 0.75 | KDM4E (0.43) | ALDH1A1ALKBH2EGLN1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106401-B1 | DERIVATIVES OF PYRROLOPYRIDINE-2-CARBOXAMIDS, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2012-03-14 | — | — | EP | disclosed |
| EP-2106401-A2 | DERIVATIVES OF PYRROLOPYRIDINE-2-CARBOXAMIDS, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2009-10-07 | — | — | EP | disclosed |
| WO-2008107543-A2 | DERIVATIVES OF PYRROLOPYRIDINE-2-CARBOXAMIDS, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2008-09-12 | — | — | WO | disclosed |