Sugi Predict

Sugi Predict / Compounds / SCHEMBL3758947

SCHEMBL3758947

SCHEMBL3758947

Cn1c(C(=O)O)cc2cccnc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MCL1 Q07820 2/20 0.56
▸ AHR P35869 1/20 0.46
▸ KDM4E B2RXH2 4/20 0.46
▸ GLA P06280 1/20 0.46
▸ ATM Q13315 1/20 0.46
▸ RXFP1 Q9HBX9 1/20 0.46
▸ ALDH1A1 P00352 4/20 0.45
▸ HPGD P15428 3/20 0.45
▸ MAPT P10636 3/20 0.45
▸ GAA P10253 1/20 0.45
▸ HSD17B10 Q99714 3/20 0.44
▸ GPR35 Q9HC97 1/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ LMNA P02545 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ SRD5A2 P31213 1/20 0.42
▸ PARP1 P09874 1/20 0.41
▸ DAO P14920 1/20 0.41
▸ MTNR1A P48039 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13575369 0.87 AHR (0.46) MCL1AHRALDH1A1MAPTPARP1
SCHEMBL23727323 0.85 PARP1 (0.47) MCL1AHRMAPTPARP1MTNR1A
SCHEMBL29813511 0.85 AHR (0.45) AHRKDM4EATMMEN1KMT2A
SCHEMBL1423541 0.83 L3MBTL1 (0.49) AHRKDM4EALDH1A1MAPTMEN1
SCHEMBL29904565 0.80 KDM4E (0.44) MCL1KDM4EALDH1A1MAPTMEN1
SCHEMBL28127748 0.80 KDM4E (0.44) MCL1KDM4EALDH1A1MAPTMEN1
SCHEMBL30226404 0.80 PARP1 (0.45) MCL1KDM4EALDH1A1MAPTMEN1
SCHEMBL1372639 0.80 AHR (0.62) AHRKDM4EALDH1A1MAPTCNR2
SCHEMBL16653325 0.80 MCL1 (0.51) MCL1AHRKDM4EGLAATM
SCHEMBL3757847 0.80 GPR35 (0.48) MCL1KDM4EATMALDH1A1GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 — — EP disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20230145249-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-05-11 — — US disclosed
US-20220332713-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2022-10-20 — — US disclosed
EP-3856178-A1 MONOACYLGLYCEROL LIPASE MODULATORS Janssen Pharmaceutica NV (BE) 2021-08-04 — — EP disclosed
CN-113164459-A Monoacylglycerol lipase modulators 詹森药业有限公司 2021-07-23 — — CN disclosed
WO-2020065613-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 — — WO disclosed
US-20200102303-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 — — US disclosed
US-20150289512-A1 METHOD FOR PROMOTING PLANT GROWTH SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-10-15 — — US disclosed
US-20150289512-A1 METHOD FOR PROMOTING PLANT GROWTH SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-10-15 — — US disclosed
US-9051296-B2 Aryl carboxamide derivatives as TTX-S blockers RAQUALIA PHARMA INC. (JP) 2015-06-09 — — US disclosed
US-9051296-B2 Aryl carboxamide derivatives as TTX-S blockers RAQUALIA PHARMA INC. (JP) 2015-06-09 — — US disclosed
CN-104093715-A 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives ACTELION PHARMACEUTICALS LTD 2014-10-08 — — CN disclosed
US-20120232052-A1 ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2012-09-13 — — US disclosed
US-20120232052-A1 ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2012-09-13 — — US disclosed
US-20100305093-A1 Inhibitors of mTOR and Methods of Making and Using EXELIXIS, INC. (US) 2010-12-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220332713-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP MCL1 1896/4885AHR 3562/4885KDM4E 2437/4885
US-20100305093-A1 Inhibitors of mTOR and Methods of Making and Using MTOR, RICTOR, RPTOR MCL1 1043/4885AHR 4422/4885KDM4E 718/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH MCL1 915/4885AHR 1488/4885KDM4E 3565/4885
US-20200102303-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP MCL1 1896/4885AHR 3562/4885KDM4E 2437/4885
US-20230145249-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP MCL1 1896/4885AHR 3562/4885KDM4E 2437/4885
US-20120232052-A1 ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS SCN1B, SCN1A, SCN2B MCL1 4211/4885AHR 340/4885KDM4E 1141/4885
US-20150289512-A1 METHOD FOR PROMOTING PLANT GROWTH FGF1, MKI67, FGF2 MCL1 3761/4885AHR 1755/4885KDM4E 2837/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP MCL1 1896/4885AHR 3562/4885KDM4E 2437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.