SCHEMBL29831763

SCHEMBL29831763

O=C(c1ccccc1)C(CC(F)F)c1ccccc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.43
CES2 O00748 2/20 0.42
CES1 P23141 2/20 0.42
CNR2 P34972 1/20 0.41
GAA P10253 2/20 0.39
MDM2 Q00987 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KCNQ2 O43526 1/20 0.37
MITF O75030 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HTT P42858 1/20 0.37
RAB9A P51151 1/20 0.37
GFER P55789 1/20 0.37
PAX8 Q06710 1/20 0.37
ATM Q13315 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
LMNA P02545 2/20 0.37
HSD17B10 Q99714 1/20 0.36
IDO1 P14902 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10779187 0.85 LMNA (0.51) HIF1ACES2CES1CNR2GAA
SCHEMBL29110200 0.81 KMT2A (0.49) HIF1ACES2CES1CNR2GAA
SCHEMBL29832525 0.80 L3MBTL1 (0.52) CES2CES1MDM2TDP1L3MBTL1
SCHEMBL8576295 0.79 HIF1A (0.42) HIF1ACES2CES1CNR2GAA
SCHEMBL2928276 0.75 TDP1 (0.55) HIF1ACES2CES1CNR2GAA
SCHEMBL23886713 0.74 CNR2 (0.46) HIF1ACES2CES1CNR2GAA
SCHEMBL30370725 0.74 CNR2 (0.46) HIF1ACES2CES1CNR2GAA
SCHEMBL23886715 0.74 CNR2 (0.46) HIF1ACES2CES1CNR2GAA
SCHEMBL29832741 0.74 HIF1A (0.38) HIF1ACES2CES1CNR2GAA
SCHEMBL29832356 0.73 NTSR1 (0.49) CES2CES1GAATDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115093367-A Preparation method and application of fluoroalkyl ketone compound 华南农业大学 2022-09-23 CN disclosed