Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29834705 | 0.81 | MAP4K4 (0.43) | MAP4K4ACACBSCN10ALRRK2CCNC | |
| SCHEMBL27096932 | 0.76 | MALT1 (0.45) | MAPTKDM4EBRAFKDRCCNC | |
| SCHEMBL27096974 | 0.74 | MAP4K4 (0.41) | MAP4K4MAPTKDM4EACACBSCN10A | |
| SCHEMBL30729909 | 0.74 | MAP4K4 (0.41) | MAP4K4MAPTKDM4EACACBSCN10A | |
| SCHEMBL16785630 | 0.73 | MAP4K4 (0.46) | MAP4K4 | |
| SCHEMBL30885063 | 0.72 | MALT1 (0.44) | MAPTKDM4EBRAFKDRALDH1A1 | |
| SCHEMBL27309672 | 0.72 | MALT1 (0.44) | MAPTKDM4EBRAFKDRALDH1A1 | |
| SCHEMBL30729928 | 0.72 | MAPK13 (0.38) | MAPK13MAPTKDRLRRK2ALDH1A1 | |
| SCHEMBL31549832 | 0.71 | MAP4K4 (0.49) | MAP4K4CA12CA1CA2CA4 | |
| SCHEMBL28170653 | 0.71 | MAP4K4 (0.49) | MAP4K4CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170043-A1 | QUINAZOLINE DERIVED COMPOUNDS AS EGFR INHIBITORS AND THEIR USES THEREOF | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2022-08-11 | — | — | WO | disclosed |