Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 2/20 | 0.52 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | PRKDC | P78527 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 16/20 | 0.46 |
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | ITK | Q08881 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | FGR | P09769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200349 | 0.89 | NUDT14 (0.62) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL29439185 | 0.88 | NUDT14 (0.61) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30416234 | 0.82 | PIK3CA (0.45) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL17626654 | 0.81 | NUDT14 (0.48) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12808147 | 0.81 | BTK (0.50) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL14617841 | 0.80 | BTK (0.52) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL15613551 | 0.79 | LCK (0.52) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30387716 | 0.79 | PIK3CD (0.65) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL16931738 | 0.79 | NUDT14 (0.49) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18235468 | 0.78 | KDR (0.49) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118027041-A | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113544130-B | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-114874286-A | Compound for degrading BTK kinase, pharmaceutical composition and pharmaceutical application thereof | 四川海思科制药有限公司 | 2022-08-09 | — | — | CN | disclosed |