Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.34 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593076 | 1.00 | ACHE (0.39) | ACHEHTR6HDAC8GCKMEN1 | |
| SCHEMBL23762163 | 0.93 | ACHE (0.39) | ACHEHTR6GCKMEN1KMT2A | |
| SCHEMBL23751139 | 0.93 | LMNA (0.37) | KMT2AALDH1A1LMNAHPGDHTT | |
| SCHEMBL21593100 | 0.92 | ACHE (0.38) | ACHEHTR6HDAC8GCKMEN1 | |
| SCHEMBL29836487 | 0.92 | ACHE (0.38) | ACHEHTR6HDAC8GCKMEN1 | |
| SCHEMBL23762108 | 0.92 | ACHE (0.42) | ACHEHTR6HDAC8GCKMEN1 | |
| SCHEMBL23762168 | 0.92 | ACHE (0.39) | ACHEHTR6HDAC8GCKMEN1 | |
| SCHEMBL21593132 | 0.92 | ACHE (0.40) | ACHEHTR6HDAC8GCKMEN1 | |
| SCHEMBL21593117 | 0.91 | NR1H2 (0.34) | HTR6MEN1KMT2ANR1H2NAMPT | |
| SCHEMBL21593184 | 0.91 | KCNA1 (0.35) | ACHEHTR6HDAC8GCKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807273-B1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2022-08-03 | — | — | EP | disclosed |